Baseline characteristics of 329 subjects with univariate and multivariate analysis of demographic and clinical factors associated with disability
| Variable | Univariate analysis | Multivariate analysis | ||
| IBD-DI (IQR) | P value | B (95% CI) | P value | |
| (Constant) | 20.79 (8.74 to 32.85) | 0.001 | ||
| Age≤35 years (n=168) | 23 (14–38) | 0.264* | −0.14 (−0.31 to 0.03)† | 0.111 |
| Age>35 years (n=161) | 23 (12–34) | |||
| Male (n=171) | 20 (11–34) | <0.001* | – | – |
| Female (n=158) | 29 (16–39) | 5.17 (1.87 to 8.47) | 0.002 | |
| Ulcerative colitis (n=137) | 21 (11–32) | 0.014* | – | – |
| Crohn’s disease (n=192) | 27 (13–39) | 1.27 (−2.35 to 4.89) | 0.491 | |
| Disease duration≤5 years (n=155) | 25 (11–36) | 0.627* | −0.07 (−0.19 to 0.32)† | 0.610 |
| Disease duration>5 years (n=174) | 23 (14–38) | |||
| Student (n=41) | 25 (12–43) | <0.001‡ | – | – |
| Employed/homemaker (n=203) | 21 (13–32) | −2.10 (−7.66 to 3.45) | 0.457 | |
| Unemployed (n=60) | 36 (23–48) | 3.36 (−3.32 to 10.04) | 0.323 | |
| Retired (n=25) | 23 (10–28) | −4.65 (−14.58 to 5.28) | 0.357 | |
| Education to 16 years (n=69)§ | 29 (17–40) | 0.080‡ | – | – |
| Education to 18 years (n=91) | 23 (11–38) | −4.03 (−8.87 to 0.81) | 0.102 | |
| Third level (university) education (n=164) | 22 (13–36) | −2.72 (−7.46 to 2.03) | 0.261 | |
| No current cigarette smoking (n=270)† | 23 (12–36) | 0.015* | – | – |
| Current cigarette smoking (n=57) | 30 (16–44) | 2.70 (−1.74 to 7.13) | 0.233 | |
| No resectional surgery (n=233) | 23 (13–34) | 0.019‡ | – | – |
| Previous bowel resection (n=72) | 29 (16–43) | 2.80 (−1.63 to 7.22) | 0.214 | |
| Permanent stoma surgery (n=24) | 26 (9–48) | −0.80 (−7.65 to 6–05) | 0.818 | |
| No current steroid (n=264) | 23 (11–34) | <0.001* | – | – |
| Current steroid (n=65) | 30 (21–43) | 7.90 (3.68 to 12.11) | <0.001 | |
| No current immune modulator (n=196) | 25 (11–38) | 0.703* | – | – |
| Current immune modulator (n=133) | 23 (14–36) | −0.11 (−3.59 to 3.37) | 0.951 | |
| No current biologic (n=230) | 23 (14–36) | 0.335* | – | – |
| Current biologic (n=99) | 25 (11–39) | 1.80 (−1.86 to 5.45) | 0.335 | |
| Inactive disease (n=241) | 20 (11–32) | <0.001* | – | |
| Active disease (n=88) | 37 (23–48) | 10.73 (6.98 to 14.47) | <0.001 | |
Dummy variables for the multivariate analysis included male sex, ulcerative colitis, retired subjects, Education to 16 years, no antidepressant use, no cigarette smoking, no resectional surgery, no steroid medications, immune modulators or biologic agents and disease remission. Univariate data are presented as medians and IQR and multivariate data as B and 95% CI.
*Mann-Whitney U test.
†Entered into multivariate model as a continuous variable.
‡Kruskal-Wallis test.
§Data not available for all cases.
IBD-DI, Inflammatory Bowel Disease Disability Index.