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  • Adjunct polymeric exclusive enteral nutrition helps achieve biochemical remission in active Crohn’s disease in adults irrespective of disease location and concomitant corticosteroid use

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Small bowel and nutrition
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Adjunct polymeric exclusive enteral nutrition helps achieve biochemical remission in active Crohn’s disease in adults irrespective of disease location and concomitant corticosteroid use
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  • Published on: 14 April 2025
    Sterile Feeding , the Microbiome,and Remission inCrohn's Disease

    Kuo et al recently showed that a polymeric enteral diet could be used to induce remission in patients with Crohn’s disease.(1) Similar results have been shown in so-called chemically-defined diets.(2,3) This now begs the question as to whether the findings in these studies have little to do with the actual dietary components, but more to do with the fact all of the manufactured enteral products used in these studies are sterile. There is surprisingly little information to be had on the role of sterile foods on the intestinal microbiome, (4) but I’ve got to believe this may be the explanation for the results in all of these studies. This potential basic mechanism wherein a sterile diet affect the microbiome diversity and perhaps other factors has largely been largely ignored while attempts have been made to peg responses to particular dietary ingredients.(5)

    1. Hellen Kuo, Katrina Tognolini, Rumbidzai Mutsekwa, Dheeraj Shukla, Laura Willmann, Hadi Moattar, Alexander Dorrington, Naveed Ishaq, Maneesha Bhullar, John Edwards, Waled Hohsen, Pradeep Kakkadasam Ramawwany. Adjunct polymeric exclusive enteral nutrition helps achieve biochemical remission in active Crohn’s disease in adults irrespective of disease location and concomitant corticosteroid use. Frontline Gastroenterol 2025; 16:3-10.
    2. Ramasatyaveni Geesala, Pratik Gongloor, Neeraja Recharla , Xuan-Zheng Shi. Mechanisms of Action of Exclusive Enteral Nutrition and Other Nutritional Therapies in Cr...

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    Conflict of Interest:
    None declared.